Seeing what the eye cannot.
PerfuVue™ is an investigational active short-wave infrared multispectral imaging platform under development for research applications in hemodynamic assessment across all skin tones.
Multiple feature-optimized SWIR bands in the 900–1700 nm range are used in this investigational multispectral imaging system. Dual-band differential analysis generates normalized perfusion signals for research purposes only.
SWIR BASELINE
SWIR absorption band captures vascular architecture beneath the dermis for investigational research imaging.
PERFUSION HEATMAP
Normalized differential signal converted to spatial perfusion intensity. Reactive hyperemia protocol reveals microvascular reserve.
TEMPORAL SIGNAL
Temporal waveform from investigational hemodynamic analysis. Measure of vascular reactivity under study for research purposes.
Closed-loop LED ring emits optimized SWIR wavelengths with diffuse reflectance calibration and relay sequencing.
High-resolution SWIR imaging sensors acquire simultaneous multi-band frames at research-grade spatial resolution.
High-performance embedded GPU compute runs KLSOSP analysis and real-time differential normalization on-device.
Hemodynamic maps and investigational indices render in the PerfuVue™ Nexus research dashboard under 21 CFR Part 11.
Multimodal (SWIR + Time-of-Flight depth + RGB + Thermal) imaging fused on a single compute platform. Three investigational modes deliver hemodynamic intelligence for research purposes.
Continuous dual-band differential imaging produces live perfusion maps during reactive hyperemia protocol. Sub-second temporal resolution captures the full vascular reactivity curve from occlusion to peak hyperemia.
FRAME RATE
0 fps
RESOLUTION
High-Res
MODALITIES
0
SWIR + ToF + RGB + IR
COMPUTE
GPU
Embedded AI Platform
KLSOSP (Kernel Least-Squares Orthogonal Subspace Projection) expert model analyzes multi-wavelength data to separate chromophore signatures. The kernel function trick projects spectral features into higher-dimensional space for robust classification across skin types.
FOSIL-WSM selected optimized wavelengths via a two-stage voting system across five ranking-band selection methods — as described in published peer-reviewed literature.
SWIR PERFUSION + ToF DEPTH FUSION
Time-of-Flight depth sensor provides millimeter-accurate depth data. Fused with SWIR perfusion maps and thermal imagery, researchers can visualize wound topology with hemodynamic state overlaid in three dimensions.
DEPTH SENSOR
ToF 3D Camera
THERMAL
Industrial Thermal
SAFETY MCU
Dual Lockstep MCUs
CALIBRATION
Diffuse Reflectance Target
PerfuVue™ is under active investigation. Published peer-reviewed data on SWIR multispectral imaging methodologies are being reviewed as part of ongoing development activities. No claims of clinical efficacy are made at this time.
SWIR imaging operates in the 900–1700 nm range where melanin absorption is negligible. This physical property suggests the potential for more equitable hemodynamic assessment across Fitzpatrick skin types I–VI compared to visible-light systems. This hypothesis is under investigation.
I
II
III
IV
V
VI
UNDER INVESTIGATION ACROSS SKIN TYPES
Relative performance of spectral classification methods studied in published literature. For research purposes only.
Three purpose-built research interfaces — investigational hemodynamic dashboard, study monitoring, and safety oversight — designed with 21 CFR Part 11 audit trail architecture. For investigational use only.
PERFUSION INDEX
—
Investigational
REACTIVITY INDEX
—
Investigational
STATUS
Planned
DESIGN
Multicenter
Multicenter study monitoring interface with enrollment tracking, site management, and protocol compliance — designed for future investigational use.
SERIOUS AEs
0
TOTAL AEs
3
Data freeze: Scheduled | Periodic review
Core innovations protected by a growing patent portfolio covering real-time hemodynamic imaging, closed-loop multimodal spectral systems, and SWIR-specific LED illumination architectures.
NON-PROVISIONAL UTILITY FILING
Non-provisional utility patent covering the complete PerfuVue™ architecture: active SWIR LED multispectral illumination with closed-loop intensity control, simultaneous multi-band capture, differential normalization, investigational scoring algorithms, and 3D perfusion topology fusion.
PROVISIONAL FILING SERIES
Multiple provisional filings protecting innovations in SWIR LED wavelength selection methodology, multimodal sensor fusion (SWIR + ToF + Thermal + RGB), safety-critical dual-MCU lockstep architecture, and closed-loop calibration for research repeatability.
Sheen, Y.J. et al. (2025)
"Advanced diabetic peripheral neuropathy detection: Validation of expert models and development of active short-wave infrared multispectral imaging techniques." Expert Systems With Applications, 269, 126462.
DOI: 10.1016/j.eswa.2025.126462 | Elsevier | CC BY-NC-ND 4.0
PerfuVue™ is being evaluated in research settings for potential applications in populations with elevated diabetes prevalence and disproportionate amputation rates, including the veteran community.
Diabetes prevalence exceeds 25% in the veteran population, with lower-extremity amputation rates remaining disproportionately high. Earlier hemodynamic assessment may support improved outcomes — this hypothesis is under investigation.
EHR DESIGN
HL7/FHIR Compatible
COMPLIANCE
21 CFR Part 11
Hemodynamic imaging in diabetic peripheral neuropathy
Cardiovascular risk stratification via perfusion analysis
Equitable assessment across diverse skin tones
Wound care hemodynamic monitoring
INVESTIGATIONAL — NOT CLEARED FOR CLINICAL USE
Founded by Garyn Angel, Quant Opt Medical Systems is dedicated to making subcutaneous hemodynamic information visible, quantifiable, and actionable. By bridging advanced photonics with research workflow, PerfuVue™ aims to enable earlier assessment of diabetic neuropathy, support cardiovascular risk research, and advance wound care science — especially for underserved populations and veterans.
PerfuVue™ is being developed under FDA De Novo classification pathway with full ISO 13485 quality management, IEC 62304 software lifecycle, ISO 14971 risk management, and 21 CFR Part 11 electronic records compliance. Dual safety MCUs in lockstep configuration provide IEC 60601-1 electrical safety with independent hardware watchdog supervision.
Garyn Angel
Founder & CEO
Combining expertise in quantitative optical systems, embedded hardware design, and medical imaging to bring SWIR hemodynamic imaging from laboratory research to the point of care.
PerfuVue™ integrates multimodal imaging sensors, high-performance embedded computing, and safety-critical microcontroller supervision on a single research platform. Technical specifications are available under NDA for qualified research partners.
Interested in PerfuVue™ for your research program or investigational study? Contact us to learn more.